Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4080 | 4080-30225 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V | L24I, F53L | L10I, K20R, M36I, R41K, D60E, I62V, I64V, I66F, A71V, T91TS |
| >4080-30225| codons 4-99 TLWQRPIVTIKIGGQLREALIDTGADDTVLEEINLPGKWKPKIIGGIGGLVKVRQYEQVL VEFCGHKVIGTVLVGPTPTNVIGRNLLSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, T215Y | D67G, K219E | Y181C, G190A | K101H | S68G, K122E, T165TI, E194K, Q197E, Q207E, R211K, D218E, L228R, V245K |
| >4080-30225| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMIKILEPFRKQNPDIVICQYMDDLYVASDLKIGEHRTKIEELREHLLKWGFYTP EEKHQKEPPFRWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |