Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4082 | 4082-30225 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A, I84V, L90M | V11I, L33F | L10V, I13V, L63P, A71V, I93L |
| >4082-30225| codons 4-99 TLWQRPVITVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFIKVRQYDQIP IEICGHKVIGTVLVGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K103N | A98G | T39A, K122E, I135IL, I142T, A158S, S162A, Q207E, R211K, L228HR |
| >4082-30225| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSLNNETPGTRYQYNVLPQGWKGSP SIFQASMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTP DKKHQKEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |