Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4081 | 4081-30225 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215FS | K103KN, Y181C | T69TN, R83K, D121Y, K122E, I135L, D177DG, I178L, E203D, L228LR |
| >4081-30225| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKKTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLYEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPGLVICQYMDDLYVGSDLEIGQHRTKIDELRQHLLRWGFSTP DKKHQKEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, G16GE, M36I, I62IV, L63LP |
| >4081-30225| codons 4-99 TLWQRPLVTIKVEGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYDQVP IEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |