Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4079 | 4079-30224 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L33I, G73S | L10I, V11L, I13V, K14R, A22V, E35D, M36I, N37D, I62V, L63P, A71V, I72V |
| >4079-30224| codons 4-99 TLWQRPILTVRIGGQLKEVLLDTGADDTVIEDIDLPGRWKPKIIGGIGGFIKVRQYDQVP IEICGHKVVSTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75VM, L210W, T215Y | K219R | T39A, E44D, V60I, W88C, V90I, V118I, K122E, A158AS, S162H, T200A, Q207E | E89EK |
| >4079-30224| codons 38-247 CAELEKDGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFCKIQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP SIFQHSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRAKIEELREHLWRWGFYTP DRKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |