Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4056 | 4056-30331 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I47V, G48V, I54M, V82A, L90M | V32I_R | L10I, L19I, R57RK, I62V, L63P, I64L, A71V, I72V, V77VI, Q92K |
| >4056-30331| codons 4-99 TLWQRPIVTIKIGGQIKEALLDTGADDTILEEMNLPGRWKPKLVVGIGGFMKVKQYDQVP LEICGHKVVGTVLIGPTPANIIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74IV, M184V, L210W, T215Y | K103N | K43N, E44D, V118I, K122E, I142V, S162SAGT, G196E, T200I, I202IT, L228LR, Q242L |
| >4056-30331| codons 38-247 CTELENDGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQTSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRIKTEELRQHLWRWGFYTP DKKHQKEPPFRWMGYELHPDKWTVLPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |