Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4055 | 4055-30218 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M, M184V | A62V, V75I, F77L, F116Y | K103KNRS, Y181C, G190GA | S68G, T69I, V90VI, A98S, K101KQ, K122KE, I135T, S163T, T165TI, I167V, I180IV, V189VI, T200A, I202V, Q207A, R211K, V245E | L228LIRS |
| >4055-30218| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKRKDGIKWRKLIDLRELNKRTQDFWEIQLGIPHP SGLQKSKSVTVLDVGDAYYSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQSTMIKVLEPFRKQNPDIVVCQYVDDLYIASDLEIGQHRAKVEELRAHLLKWGFTTP DKKHQKEPPFSWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | L24M, K55R, I62V, L63P, C67F, H69R, V77I, I85V, I93L |
| >4055-30218| codons 4-99 TLWQRPFVTIKIGGQLKEALMDTGADDTVLEEMNLPGRWKPKIIGGIGGFVRVRQYDQVP IEIFGRKAITTVLIGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |