Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4013 | 4013-30815 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 28 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | V75S, K219N | K101E, Y181C, G190A | A98G, V108I | E28K, K32E, E44D, K49R, K64R, R83K, I94L, V118I, D123E, D177E, I178F, G196E, T200A, E203D, R211K, H221Y, V245K, A272P, V292I, D324E, G333E, K350R, R356K, G359S, T386I, K390KR |
| >4013-30815| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALVEICTELEKDGKISRIGPENPYNTPV FAIRKKNSTKWRKISDFRELNKKTQDFWEVQLGLPHPGGLEKKKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEFVI CQYVDDLYVASDLEIEQHRAKIDELRQHLWKWGFYTPDNKYQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIIPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQEQGQWTYQIYQEPFKNLRTGKYAKMRSA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54S, V82T, I84V | L33F, L89V | L10V, I13V, Q18H, K20R, E35D, M36L, N37D, L63P, A71V, I72M, I93L |
| >4013-30815| codons 1-99 PQITLWQRPVVTVKIGGHLREALLDTGADDTVFEDLDLPGRWKPKIIVGIGGFSKVRQYD QIPIEICGHKVMGTVLVGPTPTNVIGRNVLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |