Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4013 | 4013-30203 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I50V, I54S, V82A | L33F, L89V | L10V, I13V, Q18QH, K20R, E35D, M36L, N37D, L63P, A71V, I72M, I93L |
| >4013-30203| codons 4-99 TLWQRPVVTVKIGGHLREALLDTGADDTVFEDLDLPGRWKPKIIVGVGGFSKVRQYDQIP IEICGHKVMGTVLVGPTPANIIGRNVLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | V75S, K219N | K101E, Y181C, G190A | A98G, V108I | E44D, K49R, K64R, R83K, I94L, V118I, D123E, D177DE, I178F, G196E, T200A, E203D, R211K, H221Y, V245K | N137NI |
| >4013-30203| codons 38-247 CTELEKDGKISRIGPENPYNTPVFAIRKKNSTKWRKISDFRELNKKTQDFWEVQLGLPHP GGLEKKKSVTILDVGDAYFSIPLDKEFRKYTAFTIPSINIETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEFVICQYVDDLYVASDLEIEQHRAKIDELRQHLWKWGFYTP DNKYQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |