<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-4011 4011-30130 Australia 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y   Y181C, G190A V108I T39A, K43E, S68G, A98S, K101Q, K102Q, V118I, K122E, I135T, T139R, S162C, V189I, G196E, L228H  
>4011-30130| codons 38-247
CAELEEEGKISKIGPENPYNTPVFAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHP
SGLQQKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNERPGIRYQYNVLPQGWKGSP
AIFQCSMTKILEPFRKQNPDIVICQYVDDLYIASDLEIEQHRTKIEELRQHLWRWGFYTP
DKKHQKEPPFHWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46MI, I47V, I54L, I84V, L90M L33F, K43T, T74P L10I, I13V, K20KR, E35ED, M36MIL, K55KR, I62V, L63P, A71V, G73GV, P79PS, I93L  
>4011-30130| codons 4-99
TLWQRPIVTVKIGGQLREALLDTGADDTIFEDLNLPGRWTPKIVGGIGGFLRVRQYDQVP
IEICGHKVIVPVLVGSTPVNVIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006