Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4011 | 4011-30130 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | Y181C, G190A | V108I | T39A, K43E, S68G, A98S, K101Q, K102Q, V118I, K122E, I135T, T139R, S162C, V189I, G196E, L228H |
| >4011-30130| codons 38-247 CAELEEEGKISKIGPENPYNTPVFAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHP SGLQQKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNERPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVICQYVDDLYIASDLEIEQHRTKIEELRQHLWRWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46MI, I47V, I54L, I84V, L90M | L33F, K43T, T74P | L10I, I13V, K20KR, E35ED, M36MIL, K55KR, I62V, L63P, A71V, G73GV, P79PS, I93L |
| >4011-30130| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTIFEDLNLPGRWTPKIVGGIGGFLRVRQYDQVP IEICGHKVIVPVLVGSTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |