Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4008 | 4008-30129 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, M36I, L63T, I64V |
| >4008-30129| codons 4-99 TLWQRPLVTIKVGGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYDQIT VEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65KR, K70KR, Q151LM, M184MV, T215TFIS | A62AV, V75VI, F77FL, F116FY | Y188L | S68SG, T69TN, K101R, K122E, E138A, T139TA, I142T, S162SC, T165TI, I178IM, V179VI, I202IV, Q207D, R211K |
| >4008-30129| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKRKDGNRWRKLIDLRELNKRTQDFWEVQLGIPHP AGLRKKKSVTVLDVGDAYYSVPLDEDFRKYTAFTIPSINNAAPGTRYQYNVLPMGWKGSP AIFQCSMIKILEPFRKQNPDMIIYQYVDDLLVGSDLEIGQHRTKVEELRDHLLKWGFSTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |