Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4006 | 4006-30128 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, G48V, I54V, V82T, I84V | L10I, I15V, K20R, M36I, L63P, I64M, A71V, I72V, Q92R |
| >4006-30128| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTILEEINLPGRWKPKMIVGIGGFVKVRQYDQIP MEICGHKVVGTVLVGPTPTNVIGRNLLTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K103N | A98G | S68G, K122P, K166R, D177E, T200A, R211RK |
| >4006-30128| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTVLDVGDAYFSVPLDPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPEIVIYQYMDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |