Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4005 | 4005-30128 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, I84V, L90M | L10F, G73T | I15V, G16A, L19I, K20I, E35D, M36IV, L63P, I64V, A71V, P79A, I85V, I93L | E34ELQV |
| >4005-30128| codons 4-99 TLWQRPFVTIKVAGQIIEALLDTGADDTVLVDVNLPGRWKPKIVGGIGGFMKVRQYDQIP VEICGHKVITTVLVGATPVNVVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, V75T, L210W, T215Y | A62V, K219N | Y181C, Y188L | K43E, E44A, V118I, K122E, I135T, S162A, V189I, T200A, E203D, H208Y, R211K, K223Q, L228R |
| >4005-30128| codons 38-247 CTELEEAGKISKIGPENPYNTPVFVIKKKNSDKWRKITDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFRKQNPDIVICQYMDDLLIGSDLEIGQHRAKIDELRQYLWKWGFYTP DNKHQQEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |