Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4004 | 4004-30128 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A | L23I, F53L | L10I, R41K, D60E, I62V, L63P, A71V, I93L |
| >4004-30128| codons 4-99 TLWQRPIVTIKIGGQLKEAILDTGADDTVLEEMNLPGKWKPKIIGGIGGLVKVRQYEQVP IEICGHKVIGTVVVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L210W, T215Y | A62V, V75I | K103N | T39A, E44ED, S68SG, A98AS, K101Q, V118VI, K122E, D123S, E138Q, I142T, S162ST, R172RK, I178L, Q207E, R211K |
| >4004-30128| codons 38-247 CAELEKDGKISKIGPENPYNTPVFVIKKKNGTKWRKLIDFRELNKRTQDFWEVQLGIPHP SGLQKNKSVTVLDVGDAYFSIPLDESFRKYTAFTIPSINNQTPGTRYQYNVLPQGWKGSP AIFQTSMTKILEPFKKQNPDLVIYQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |