Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4003 | 4003-30128 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82S | L24I, L33F, G73GS | L10I, N37T, K55R, I62V, L63P, I66IF, A71V |
| >4003-30128| codons 4-99 TLWQRPIVTIKIGGQLKEALIDTGADDTVFEEMTLPGRWKPKIIGGIGGFVRVRQYDQVP IEFCGHKVISTVLVGPTPSNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LI, L210W, T215Y | K43KE, V60VI, K122E, Q197K, Q207QE, R211K |
| >4003-30128| codons 38-247 CTELEEEGKISKIGPENPYNTPIFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGKHRTKIEELREHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |