Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4001 | 4001-30124 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, M184V, T215F | K219Q | Y181C, G190A | K101H, V108I, P225PH | K43N, K122E, S162D, V179VI, V189VI, Q197P, T200I, R211K, D218E |
| >4001-30124| codons 38-247 CTELENEGKISKIGPENPYNTPVFAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPDIIICQYVDDLYIASDLEIGPHRIKIEELRQHLLKWGFFTP EQKHQKEHPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73S | I13V, Q18H, K20I, M36I, L63P, A71V, I72L |
| >4001-30124| codons 4-99 TLWQRPFVTVKIGGHLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYDQIP IEICGHKVLSTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |