Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4002 | 4002-30124 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48MV, I54S, V82A, L90M | L33F, K43T | L10V, I13V, Q18QH, K20R, L24LF, E35D, M36I, N37D, I62V, L63P, A71I, I93L |
| >4002-30124| codons 4-99 TLWQRPVVTVKIGGHLREALFDTGADDTVFEDIDLPGRWTPKMIVGIGGFSKVRQYDQVP IEICGHKIIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, Y115YF, M184V | D67G, T215TI, K219N | V106M, G190GA | V179D | S68G, K103R, V118I, I135T, T165I, Q207E, R211RK, F214L, D237N |
| >4002-30124| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKRKSMTVLDVGDAFFSIPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMIKILEPFRKQNPDIDIYQYVDDLYVASDLEIGQHRTKIEELREHLLKWGLITP DNKHQKEPPFLWMGYELHPNKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |