Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4051 | 4051-30822 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10F, V11VI, L33I | T12K, I13V, L19LP, K20M, E35D, M36I, N37D, I62V, L63P, I66F, A71T, I93L, C95F |
| >4051-30822| codons 4-99 TLWQRPFIKVKIGGQPMEALLDTGADDTVIEDIDLPGRWKPKIIGGIGGFVKVRQYDQVP IEFCGHKTIGTVLVGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70KR, L74V, V75M, M184V | K219KQ | Y181YC | K43E, K64H, T69N, V118I, K122E, I135T, T200A, F214L, L228H |
| >4051-30822| codons 38-247 CTEMEEEGKISKIGPENPYNTPVFAIHKKDSNRWRKVMDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGLTTP DQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |