Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4050 | 4050-30820 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10F, G73S | I15V, L19P, K20V, L24F, E34Q, M36I, N37D, I62V, L63P, A71V, I72L, P79D, I93L |
| >4050-30820| codons 4-99 TLWQRPFVTIKVGGQPVEALFDTGADDTVLQEIDLPGRWKPKMIGGIGGFVKVRQYDQVP IEICGHKVLSTVLVGDTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, V75M, M184V, L210W, T215Y | D67G, F77L, K219N | K103N | K43E, E44A, K64H, S68G, V118I, K122E, I142V, D177G, I178IM, G196E, T200A, E203EA, Q207E, R211K, L228H, Q242H, V245E |
| >4050-30820| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIHKKGGTKWRKIMDLRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPGMVIYQYVDDLYVGSDLEIEQHRAKIAELREHLWKWGFYTP DNKHQKEPPFHWMGYELHPDKWTVHPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |