Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4049 | 4049-30724 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54A, V82T | L24I, F53L | L10I, K14R, N37ND, I62V, L63E, I64V, E65D, A71T, I72V, T74S, V77I, I93L |
| >4049-30724| codons 4-99 TLWQRPIVTIRIGGQLKEALIDTGADDTVLEEMDLPGRWKPKMIMGIGGLAKVRQYDQVE VDICGHKTVGSVLIGPTPTNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | D67G, K219R | T39K, K43E, E44D, V60I, T69Y, V118I, S162SC, V179VI, H208Y, R211D, D218E, L228H, V245M |
| >4049-30724| codons 38-247 CKELEEDGKISKIGPENPYNTPIFAIKKKGSYKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIIIYQYMDDLYVGSDLEIGQHRTKIEELRQYLWDWGFYTP ERKHQKEPPFHWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |