Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4048 | 4048-30714 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, L90M | G73C | L10R, I15V, L19P, K20I, E35G, M36L, N37T, P39S, K55R, Q61D, I62V, L63P, C67L, A71T, I72T, T74S, Q92K |
| >4048-30714| codons 4-99 TLWQRPRVTIKVGGQPIEALLDTGADDTVLEGLTLSGRWKPKLIGGIGGFIRVRQYDDVP IEILGHKTTCSVLVGPTPVNIIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | D67E | Y181YC, G190GA | K101H | T39D, K43KR, E44D, S68G, V118I, K122E, V189VI, Q207E, H208F, R211RK, V245E | K103KI |
| >4048-30714| codons 38-247 CDELERDGKISKIGPENPYNTPVFAIKKKEGTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLHKIKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYIASDLEIGQHRTKIEELREFLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |