Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4047 | 4047-30910 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 12 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, V75M, M184V, L210W, T215Y | K219R | G190A | A98G, V108I, F227L | T39A, K43E, E44D, V118I, K122E, D123DN, I135T, S162C, V189I, E203K, Q207E, H208Y, R211K, K223E, L228LH, D237E, V245M |
| >4047-30910| codons 38-247 CAELEEDGKISKIGPENPYNTPVFAIKKKNSDKWRKVMDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTILDVGDAYFSIPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYVDDLYIASDLEIGQHRTKIKELREYLWKWGFYTP DRKHQEEPPLHWMGYELHPEKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, M46I, I54V, V82A | L24I, L33F, K43T, N88D | L10I, I15V, E34V, E35D, M36L, I62V, L63P, A71T, I72T, V75I |
| >4047-30910| codons 4-99 TLWQRPIVTIKVGGQLKEALIDTGADNTVFVDLNLPGRWTPKIIGGIGGFVKVRQYDQVP IEICGHKTTGTILVGPTPANIIGRDLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |