<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-4046 4046-30514 Australia 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54S, V82A, L90M L33F L10I, I13V, K20R, E35D, M36I, R41K, I62V, L63P, A71I, I72M, I93L  
>4046-30514| codons 4-99
TLWQRPIVTVKIGGQLREALLDTGADDTVFEDINLPGKWKPKMIVGIGGFSKVRQYDQVP
IEICGHKIMGTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, L210W, T215Y K219R K103N V108I, K238T K43Q, E44D, V118I, K122E, I135M, K173T, R211K, D218E, Q242H, V245K  
>4046-30514| codons 38-247
CTELEQDGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRTQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTP
ERKHQKEPPFLWMGYELHPDTWTVHPIKLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006