Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4045 | 4045-30331 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10F, L33LF, K43KT | L19I, K20R, E35D, M36I, K55R, R57K, L63P, A71V, T91S, Q92QK, I93L, C95F |
| >4045-30331| codons 4-99 TLWQRPFVTIKIGGQIREALLDTGADDTVFEDINLPGRWTPKLIGGIGGFVRVKQYDQIP IEICGHKVIGTVLVGPTPANIIGRNLMSKLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | T215I, K219Q | K103KN | P225PH | T39TK, K46KQ, T69N, R83K, V118I, S162Y, F214L, L228LR |
| >4045-30331| codons 38-247 CKEMEKEGQISKIGPENPYNTPVFAIKKKDSNRWRKLVDFRELNKKTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLITP DQKHQKEHPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |