Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4044 | 4044-30306 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | G73S, L89V | L10I, L33M, E34Q, N37T, L63P, A71V, I72V, I93L |
| >4044-30306| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTIMQEMTLPGRWKPKIVGGIGGFMKVRQYDQIP IEICGHKVVSTVLVGPTPANIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Q151M | V75VI, F77L, F116Y, T215TAIV, K219Q | G190A | D121DY, K122E, D123E, S162SDGN, R211I, V245T |
| >4044-30306| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYYSVPLYEEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQNSMTKILEPFRKQNPDIVIYQYMDDLYVASDLEIGQHRTKIEELRQHLLIWGFVTP DQKHQKEPPFLWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |