<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-4043 4043-30305 Australia 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74I, M184V, L210W, T215Y K219KR K103S, G190A V108I K43E, E44D, E53D, V118I, K122E, R172K, D177G, T200E, E203K, Q207E, R211K, K223Q  
>4043-30305| codons 38-247
CTELEEDGKISKIGPDNPYNTPVFAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGIPHP
AGLKKSKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFKKQNPGIVIYQYVDDLYVASDLEIGQHREKIKELREHLWKWGFYTP
DRKHQQEPPFLWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, G73S I15V, K20I, A22V, M36I, L38LF, I62V, L63P, C67F, A71V, I72L, N83S, I85V  
>4043-30305| codons 4-99
TLWQRPFVTIKVGGQLIEVLLDTGADDTVLEEINFPGRWKPKIIGGIGGFVKVRQYDQVP
IEIFGHKVLSTVLVGPTPVSVVGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006