Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4032 | 4032-30225 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82F, L90M | F53L | L10I, N37S, A71V, V77I, I93L |
| >4032-30225| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKIVGGIGGLVKVRQYDQIL IEICGHKVIGTVLIGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | K103HN, Y181C, G190A | A98G | K43Q, K122E, T139TK, I142IT, V179I, R211K, V245M |
| >4032-30225| codons 38-247 CTELEQEGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNEKPGTRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYVDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |