Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4060 | 4060-30716 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, L76V, V82A | L33F, K43T, L89V | L10V, I13V, K14R, K20M, M36I, K55R, L63P, A71V, T91A, Q92K |
| >4060-30716| codons 4-99 TLWQRPVVTVRIGGQLMEALLDTGADDTIFEEINLPGRWTPKIIGGIGGFVRVRQYDQIP IEICGHKVIGTVVVGPTPANIIGRNVLAKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69DE, K70R, L74V, V75T, Y115F, M184V, T215F | K219Q | K103N | V118I, K122E, I135V, K173E, T200A, E203D, F214L, L228LIV |
| >4060-30716| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSERWRKVTDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAFFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFREQNPDIVIYQYVDDLYVGSDLEIGQHRAKIDELRQHLLRWGLFTP DQKHQKEPPFVWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |