Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4059 | 4059-30716 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, G48V, I50V, I54T, V82A | L33I, Q58E | L10I, I13V, K20R, E34Q, E35D, M36I, L63P, A71I, I72V, I93L |
| >4059-30716| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTVIQDINLPGRWKPKIIVGVGGFTKVREYDQIP IEICGHKIVGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69T_ES, L210W | D67DE | Y181YC | S68SN, W88C, A98S, K122E, Q207QP, R211K, L228H |
| >4059-30716| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKENTKWRKLVDFRELNKRTQDFCEVQLGIPHP SGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRPHLWKWGFTTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |