Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4025 | 4025-30616 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | L10F, V11I, Q58E, G73S | I13V, I15V, K20I, E35N, M36I, N37D, K55R, D60E, Q61E, I62V, L63P, A71IT, I72T, I93L |
| >4025-30616| codons 4-99 TLWQRPFITVKVGGQLIEALLDTGADDTVLENIDLPGRWKPKIVGGIGGFVRVREYEEVP IEICGHKTTSTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K103H, Y181C, G190A | V108I | K43Q, K64R, K101Q, V118I, K122E, E169D, V179I, T200A, E203D, H208Y, R211K, H221Y, L228H |
| >4025-30616| codons 38-247 CTELEQEGKISKIGPENPYNTPVFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKHKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILDPFRKQNPDIIICQYVDDLYVASDLEIGQHRAKIDELRQYLWKWGFYTP DNKYQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |