<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-4025 4025-30616 Australia 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, I84V, L90M L10F, V11I, Q58E, G73S I13V, I15V, K20I, E35N, M36I, N37D, K55R, D60E, Q61E, I62V, L63P, A71IT, I72T, I93L  
>4025-30616| codons 4-99
TLWQRPFITVKVGGQLIEALLDTGADDTVLENIDLPGRWKPKIVGGIGGFVRVREYEEVP
IEICGHKTTSTVLVGPTPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219N K103H, Y181C, G190A V108I K43Q, K64R, K101Q, V118I, K122E, E169D, V179I, T200A, E203D, H208Y, R211K, H221Y, L228H  
>4025-30616| codons 38-247
CTELEQEGKISKIGPENPYNTPVFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLQKHKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILDPFRKQNPDIIICQYVDDLYVASDLEIGQHRAKIDELRQYLWKWGFYTP
DNKYQKEPPFHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006