<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-4022 4022-30527 Australia 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48V, I54T, V82T L24I L10I, T12P, K14R, I15V, K20M, E35D, M36I, R41K, L63P, A71I, I72V  
>4022-30527| codons 4-99
TLWQRPIVPIRVGGQLMEALIDTGADDTVLEDINLPGKWKPKIIVGIGGFTKVRQYDQIP
IEICGHKIVGTVLVGPTPTNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69AD, V75M, L210W, T215Y K219R K101E, K103KT, G190A A98G, V108VI T39TK, K43E, E44ED, V60I, K65KE, V118I, K122E, I135L, G196E, T200TA, H208HY, R211K, K223KQ, L228LH, V245I E53EA, N57NH
>4022-30527| codons 38-247
CKELEEDGKISKIGPANPYHTPIFAIKEKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHP
GGLEKTKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVASDLEIEQHRAKIEELRQYLWKWGFYTP
DRKHQQEPPFHWMGYELHPDKWTVQPIILP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006