Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4022 | 4022-30527 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54T, V82T | L24I | L10I, T12P, K14R, I15V, K20M, E35D, M36I, R41K, L63P, A71I, I72V |
| >4022-30527| codons 4-99 TLWQRPIVPIRVGGQLMEALIDTGADDTVLEDINLPGKWKPKIIVGIGGFTKVRQYDQIP IEICGHKIVGTVLVGPTPTNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69AD, V75M, L210W, T215Y | K219R | K101E, K103KT, G190A | A98G, V108VI | T39TK, K43E, E44ED, V60I, K65KE, V118I, K122E, I135L, G196E, T200TA, H208HY, R211K, K223KQ, L228LH, V245I | E53EA, N57NH |
| >4022-30527| codons 38-247 CKELEEDGKISKIGPANPYHTPIFAIKEKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHP GGLEKTKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVASDLEIEQHRAKIEELRQYLWKWGFYTP DRKHQQEPPFHWMGYELHPDKWTVQPIILP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |