Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4039 | 4039-30516 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219E | K103N | V108I, L234I | K43N, E44D, K122E, I142V, V179VI, T200A, R211K, D218E, V245K |
| >4039-30516| codons 38-247 CTELENDGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTP EEKHQKEPPFLWMGYEIHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V, L90M | L10F, G73S | I13V, K20M, M36I, K55R, I62V, L63P, I64IV, A71T, I72T, I93L |
| >4039-30516| codons 4-99 TLWQRPFVTVKIGGQLMEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFMRVRQYDQVP VEICGHKTTSTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |