Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4037 | 4037-30507 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11I, L33LF, G73S | I13V, L19I, K20I, E35D, M36ML, K55R, I62V, L63P, C67F, H69R, A71V, I72L, N83S, T91S |
| >4037-30507| codons 4-99 TLWQRPFITVKIGGQIIEALLDTGADDTVFEDLNLPGRWKPKIIGGIGGFVRVRQYDQVP IEIFGRKVLSTVLVGPTPVSVIGRNLMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74LI, L210W, T215F | K219E | Y181C, G190A | K101H, V108VI | K66R, T69N, V118VI, K122E, Q207E, D218E, L228R |
| >4037-30507| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKRNSNRWRKIVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRTKIEELREHLWRWGFFTP EEKHQKEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |