Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4094 | 4094-30505 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | K43T, G73C | L10I, I15V, K20KR, E35D, M36I, I62V, L63P, I66L, I72L |
| >4094-30505| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTILEDINLPGRWTPKIVGGIGGFMKVRQYDQVP IELCGHKALCTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| S68G, S163SI, I178M, H208HY, R211RK, V245M |
| >4094-30505| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSIMTKILEPFRKQNPDMVIYQYMDDLYVGSDLEIGQHRTKIEELRQYLLKWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |