<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-4093 4093-30424 Australia 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, I84V, L90M L10F, V11I, G73S, L89V I13V, L33M, N37ND, I62V, L63P, A71V, I93L  
>4093-30424| codons 4-99
TLWQRPFITVKIGGQLKEALLDTGADDTVMEEMDLPGRWKPKMIGGIGGFVKVRQYDQVP
IEICGHKVISTVLVGPTPVNVIGRNVMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, T215F V75T, K219Q K103KN, Y181C, G190GA V108I A98S, V118I, K122E, D123N, S162D, Q174K, N175Y, D177E, I178M, V179I, V189VI, G196E, E203D, Q207E, H208Y, R211K, F214L, D218E, H221Y, L228H, Q242H T69Y
>4093-30424| codons 38-247
CTELEKEGKISKIGPENPYNTPVFAIKKKNSYRWRKITDFRELNKRTQDFWEVQLGIPHP
SGLKKNKSVTILDVGDAYFSIPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQDSMTKILEPFRKKYPEMIICQYMDDLYIASDLEIEQHRTKIDELREYLLKWGLFTP
EQKYQKEPPFHWMGYELHPDKWTVHPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006