Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4092 | 4092-30410 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Q151M | K219E | Y181C | S68G, K122Q, I135V, L168*, I178L, V179I, R211K, L228R, V245VA | D113H |
| >4092-30410| codons 38-246 CTEMEKEGKISKIGPENPYNTPVFAIKRKDGTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGHAYFSVPLDQDFRKYTAFTIPSVNNETPGIRYQYNVLPMGWKGSP AIFQSSMTKI*EPFRKQNPDLIICQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTP DEKHQKEPPFRWMGYELHPDKWTVQPIAL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| R41K, V77I, I93L |
| >4092-30410| codons 4-99 TLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYDQIL IEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |