Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4091 | 4091-30325 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, M184V, T215Y | D67H, K219E | T39A, T69N, A98S, K122E, I135T, T200A, L228H, V245M |
| >4091-30325| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKHSNRWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFYTP DEKHQKEPPFHWMGYELHPDKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V, L90M | L33F | L10I, I13V, K14R, E35D, N37S, K55KR, Q61QH, I62V, L63P, I66IV, H69R, A71T, I72E, I93L, C95F |
| >4091-30325| codons 4-99 TLWQRPIVTVRIGGQLKEALLDTGADDTVFEDMSLPGRWKPKIIGGIGGFVRVRQYDHVP IEVCGRKTEGTVVVGPTPVNVIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |