Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4078 | 4078-30324 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82S, L90M | L10I, K20R, E35D, M36I, N37D, R57K, I62V, L63P, A71T, I93L, C95F |
| >4078-30324| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVKQYDQVP IEICGHKTIGTVLVGPTPSNIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, Y115F, M184V | T215S | Y181C, G190A | A98S, V106I, K122E, V179I, T200A, Q207N, K223KR, Q242R | K101V |
| >4078-30324| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP SGLVKKKSITVLDVGDAFFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYVDDLYVASDLEIGQHRAKIEELRNHLLRWGFSTP DKKHQREPPFLWMGYELHPDKWTVRPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |