<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-4075 4075-30307 Australia 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, L210W, T215Y V75T, K219N L100I, K103N   K43N, I50IM, A98S, V118I, K122E, I135T, S162N, G196E, E203K, Q207E, R211K, K223E, L228R  
>4075-30307| codons 38-247
CTELENEGKISKMGPENPYNTPVFAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHP
SGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQNSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRTKIKELREHLWKWGFYTP
DNKHQEEPPFRWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48V, I54V, V82ST, L90M G73GS L10IV, I15V, G16GW, L19T, K20T, E35D, R41K, Q61HN, I62V, L63P, A71AT, I72V, T74S, V77I, I93L, C95F L24LW
>4075-30307| codons 4-99
TLWQRPVVTIKVWGQTTEALWDTGADDTVLEDMNLPGKWKPKLIVGIGGFVKVRQYDNVP
IEICGHKTVSSVLIGPTPTNIIGRNLMTQLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006