Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4074 | 4074-30306 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, L210W, T215Y | K219E | K103N | V108I, L234I | V60I, T69N, A98S, K122E, G196GE, E203K, Q207E, R211K, D218E, K223T, L228H |
| >4074-30306| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSNKWRKITDFRELNKRTQDFWEVQLGIPHP SGLKKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTKIKELREHLWKWGFYTP EEKHQTEPPFHWMGYEIHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46ML | K43KT | L10LI, I15IV, K20KR, E35D, M36MI, N37AD, L63P |
| >4074-30306| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTILEDIDLPGRWTPKLIGGIGGFIKVRQYDQIP IEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |