Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4072 | 4072-30305 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, L210W, T215Y | K219Q | Y181C, G190A | T39E, E44D, V60I, R83K, V106VI, V118I, K122E, I135T, S162A, Q207E, D218E, L228H, V245E |
| >4072-30305| codons 38-247 CEELEKDGKISKIGPENPYNTPIFAIKKKNSDKWRKLMDFRELNKKTQDFWEVQLGIPHP AGLKKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRTKIEELREHLWRWGFYTP EQKHQKEPPFHWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | L33I, G73S | L10I, I13V, E34Q, M36MIL, I62V, L63P, A71T, I72V, Q92K |
| >4072-30305| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTVIQELNLPGRWKPKMIGGIGGFLKVRQYDQVP IEICGHKTVSTVLVGPTPVNVIGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |