<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-4072 4072-30305 Australia 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, V75M, L210W, T215Y K219Q Y181C, G190A   T39E, E44D, V60I, R83K, V106VI, V118I, K122E, I135T, S162A, Q207E, D218E, L228H, V245E  
>4072-30305| codons 38-247
CEELEKDGKISKIGPENPYNTPIFAIKKKNSDKWRKLMDFRELNKKTQDFWEVQLGIPHP
AGLKKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQASMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRTKIEELREHLWRWGFYTP
EQKHQKEPPFHWMGYELHPDKWTVQPIELP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54L, I84V, L90M L33I, G73S L10I, I13V, E34Q, M36MIL, I62V, L63P, A71T, I72V, Q92K  
>4072-30305| codons 4-99
TLWQRPIVTVKIGGQLKEALLDTGADDTVIQELNLPGRWKPKMIGGIGGFLKVRQYDQVP
IEICGHKTVSTVLVGPTPVNVIGRNLMTKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006