Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4073 | 4073-30305 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47IV, I54V, I84V, L90M | L10F, V11I, L33LI, N88D | T12S, I15V, L19Q, K20I, E35D, M36I, N37D, Q61QH, L63P, A71T, I85V, Q92R | T91TCS |
| >4073-30305| codons 4-99 TLWQRPFISIKVGGQQIEALLDTGADDTVIEDIDLPGRWKPKIVGGIGGFVKVRQYDHIP IEICGHKTIGTVLVGPTPVNVVGRDLMSRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75M, L210W, T215Y | K219DH | K103N, Y181C | V108I | T39A, V60I, K101KQ, K122E, I135T, E194K, G196E, E203EK, H208HY, R211K, D218E, L228H, Q242K | K223PT |
| >4073-30305| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSDRWRKLMDFRELNKRTQDFWEVQLGIPHP AGLQKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLKIEQHRTKIKELRQYLWKWGFYTP EHKHQTEPPFHWMGYELHPDKWTVKPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |