Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4071 | 4071-30227 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, Y115YF, M184MV, T215Y | L100I, Y188L | V90VI, K122E, I135V, T139TA, V179VI, G196E, T200TK, V245K |
| >4071-30227| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEIQLGIPHP AGIKKKKSVTVLDVGDAFFSVPLDEDFRKYTAFTIPSVNNEAPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYVDDLLVGSDLEIEQHRKKIEELRQHLLRWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47IV, I54V, I84V, L90M | G73S, L89V | L10H, I13V, I15IV, K20I, E35D, M36I, N37D, L63P, A71V, T91S, I93L |
| >4071-30227| codons 4-99 TLWQRPHVTVKVGGQLIEALLDTGADDTVLEDIDLPGRWKPKIVGGIGGFVKVRQYDQIP IEICGHKVISTVLVGPTPVNVIGRNVMSQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |