Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4068 | 4068-30221 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70G, L74V | K103N, Y181C | S68N, T69A, K122E, I135L, Q174R, R211K, V245E |
| >4068-30221| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDNAGWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | V11I, G73GS | L10I, I15V, K20V, M36I, K55KR, D60E, I62V, L63P, A71T, I72T, I85V |
| >4068-30221| codons 4-99 TLWQRPIITIKVGGQLVEALLDTGADDTVLEEINLPGRWKPKLIGGIGGFVRVRQYEQVP IEICGHKTTSTVLVGPTPVNVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |