<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3049 3049-30508 Canada 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y K219KN K103N, Y181C, G190GA   T39E, E44ED, S48ST, V60I, K64R, V118I, K122E, I135T, S162SAGT, T165I, R172RK, K173A, Q174QR, D177E, T200A, E203EK, E204EK, Q207E, R211RK, D218E, V245Q  
>3049-30508| codons 38-247
CEELEKDGKITKIGPENPYNTPIFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQTSMIKILEPFKARNPEIVICQYMDDLYVASDLEIGQHRAKIKKLREHLWKWGFYTP
ENKHQKEPPFLWMGYELHPDKWTVQPIQLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A, L90M L10FI I15V, L19T, K20I, E35DN, M36I, R41K, Q61H, L63P, H69K, A71V, T74S, I85V, L89I, T91S, I93L W6W*
>3049-30508| codons 4-99
TL*QRPIVTIKVGGQTIEALLDTGADDTVLENINLPGKWKPKIIGGIGGFVKVRQYDHIP
IEICGKKVIGSVVVGPTPANIVGRNIMSQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006