Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3049 | 3049-30508 | Canada | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A, L90M | L10FI | I15V, L19T, K20I, E35DN, M36I, R41K, Q61H, L63P, H69K, A71V, T74S, I85V, L89I, T91S, I93L | W6W* |
| >3049-30508| codons 4-99 TL*QRPIVTIKVGGQTIEALLDTGADDTVLENINLPGKWKPKIIGGIGGFVKVRQYDHIP IEICGKKVIGSVVVGPTPANIVGRNIMSQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219KN | K103N, Y181C, G190GA | T39E, E44ED, S48ST, V60I, K64R, V118I, K122E, I135T, S162SAGT, T165I, R172RK, K173A, Q174QR, D177E, T200A, E203EK, E204EK, Q207E, R211RK, D218E, V245Q |
| >3049-30508| codons 38-247 CEELEKDGKITKIGPENPYNTPIFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQTSMIKILEPFKARNPEIVICQYMDDLYVASDLEIGQHRAKIKKLREHLWKWGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |