<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3050 3050-31120 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 28

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, L74I, M184V, T215F K219Q K103N A98G, V108I T39TA, V60I, A158S, K173Q, I178M, V179I, G196E, Q197K, Q207E, H208Y, R211K, D218E, L228H, V245E  
>3050-31120| codons 38-247
CAELEKEGKISKIGPENPYNTPIFAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHP
GGLKKNKSVTILDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
SIFQSSMTKILEPFRQQNPDMIIYQYVDDLYVGSDLEIEKHRTKIEELREYLLKWGFFTP
EQKHQKEPPFHWMGYELHPDKWTVQPIELP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I50V, I54T, V82A L33F L10I, K20R, E34R, E35D, M36I, R41K, L63P, A71V, I72IM, I93L  
>3050-31120| codons 4-99
TLWQRPIVTIKIGGQLREALLDTGADDTVFRDINLPGKWKPKMIVGVGGFTKVRQYDQIP
IEICGHKVMGTVLVGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006