Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3050 | 3050-31120 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 28 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, M184V, T215F | K219Q | K103N | A98G, V108I | T39TA, V60I, A158S, K173Q, I178M, V179I, G196E, Q197K, Q207E, H208Y, R211K, D218E, L228H, V245E |
| >3050-31120| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTILDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP SIFQSSMTKILEPFRQQNPDMIIYQYVDDLYVGSDLEIEKHRTKIEELREYLLKWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54T, V82A | L33F | L10I, K20R, E34R, E35D, M36I, R41K, L63P, A71V, I72IM, I93L |
| >3050-31120| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVFRDINLPGKWKPKMIVGVGGFTKVRQYDQIP IEICGHKVMGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |