Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3050 | 3050-30508 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, M184MV, T215F | K219Q | K103N | A98G, V108I | V60I, A158S, K173Q, I178M, V179I, G196E, Q197K, Q207A, H208HY, R211K, L228H, V245E |
| >3050-30508| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTILDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP SIFQSSMTKILEPFRQQNPDMIIYQYVDDLYVGSDLEIEKHRTKIEELRAYLLKWGFFTP DQKHQKEPPFHWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54T, V82A | L33F | L10I, K20R, E34K, E35D, M36I, R41K, L63P, A71V, I93L |
| >3050-30508| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVFKDINLPGKWKPKMIVGVGGFTKVRQYDQIP IEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |