Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3047 | 3047-30325 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, T215F | V75VA, K219Q | K103N, Y181YC, G190GA | F227L | V60I, K82KR, V90VI, K122KE, D123DN, I135T, R172RK, T200A, E203K, Q207A, R211K, K223E, L228H, V245T |
| >3047-30325| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKIADFRELNRRTQDFWEIQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFKKQNPDIVICQYMDDLYVASDLEIGQHRAKIKELRAHLLKWGFFTP DQKHQEEPPLHWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L24I, L33F, Q58E | L10I, I13V, I15V, K20T, E35D, M36I, N37NS, R41K, R57RK, L63P, A71AT, I72V, V75VI |
| >3047-30325| codons 4-99 TLWQRPIVTVKVGGQLTEALIDTGADDTVFEDISLPGKWKPKMIGGIGGFVKVKEYDQIP IEICGHKTVGTILVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |