<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3047 3047-30325 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A L24I, L33F, Q58E L10I, I13V, I15V, K20T, E35D, M36I, N37NS, R41K, R57RK, L63P, A71AT, I72V, V75VI  
>3047-30325| codons 4-99
TLWQRPIVTVKVGGQLTEALIDTGADDTVFEDISLPGKWKPKMIGGIGGFVKVKEYDQIP
IEICGHKTVGTILVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, L74I, T215F V75VA, K219Q K103N, Y181YC, G190GA F227L V60I, K82KR, V90VI, K122KE, D123DN, I135T, R172RK, T200A, E203K, Q207A, R211K, K223E, L228H, V245T  
>3047-30325| codons 38-247
CTEMEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKIADFRELNRRTQDFWEIQLGIPHP
AGLKKNKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFKKQNPDIVICQYMDDLYVASDLEIGQHRAKIKELRAHLLKWGFFTP
DQKHQEEPPLHWMGYELHPDKWTVQPITLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006