Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3065 | 3065-30331 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219R | K103N | A98G | T39A, K43KE, E44D, V118I, K122E, I135T, S162Y, Q174K, N175Y, T200K, K201I, E203ED, Q207D, H208FY, R211K, L228H |
| >3065-30331| codons 38-247 CAELEEDGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKKYPDIVIYQYVDDLYVGSDLEIGQHRKIIDELRDYLWKWGFYTP DRKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48S, I54V, V82F, L90M | L10I, I13V, K20I, E35D, M36I, N37D, R41K, K45V, F53Y, D60E, I62V, I64V |
| >3065-30331| codons 4-99 TLWQRPIVTVKIGGQLIEALLDTGADDTVLEDIDLPGKWKPVIISGIGGYVKVRQYEQVL VEICGHKAIGTVLVGPTPFNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |